A two-floor atrium lobby with striking asymmetrical white walls, LED lighting, and globe chandeliers offers a slightly surprising contrast to the rather regular-looking exterior of this 10-story hotel building. Hallways feature wood panels, lit plexi block-signs, and '60s-style burnt-orange couches for an overall mod design feel. The hotel attracts a mix of couples on vacation and business clients. Overall the atmosphere is slick and polished, from the stylish lobby to the rooftop pool and bar.

The EPIC SANA Lisboa Hotel sits on a fairly busy road, about a 12-minute walk from Marques de Pombal Square, and 15 minutes on foot from the luxury shopping at Avenida da Liberdade. The area immediately around the hotel is filled with other mid-rise buildings and larger residential buildings. The smaller streets around the Rato metro stop provide some boutique shopping and restaurants are within a 15-minute walk. Guests should note that coming back to the hotel requires a slight uphill climb. There are several bus lines within a couple of blocks, and those wishing to take public transportation to the airport can catch a bus that stops a few hundred feet from the hotel (about 35 minutes).

Teal chenille throws, white paneled walls, velvet couches, and wood veneer built-ins lend distinctly '60s color and design aesthetics to these modern rooms. They also have either large LCD TVs or monitors integrated into the gigantic mirror facing the bed. Larger rooms have tulip chairs and tables and a separate living area. Nespresso coffee machines and professional hairdryers in the bathroom add to the contemporary technology. All rooms include digital safes, bathrobes and slippers, a snack selection, a fully stocked minibar, and marble-tiled bathrooms with square porcelain sinks and glassed-in showers. Guests may want to note that, while there is the option to pull down a set of shades, the bathroom wall adjoining the bedroom is made entirely of glass.

The large spa features an array of treatment rooms, handsomely lined with gold mosaic tiles. The indoor pool’s lounge area offers snacks and fruit-infused water. There is an outdoor rooftop pool and an adjacent bar that affords beautiful views of the city, and a sizable fitness center with several banks of updated exercise equipment and weight machines. Wi-Fi is free throughout the property. Visitors have generally given positive reviews to the bar and restaurant, though have noted that both are quite pricey and service can be slow.