Unlike most of the other buildings in the area, the hotel is housed in a modern red-brick building. Inside, a reception area is wrapped in classic green wooden paneling, which adds a touch of elegance to the space. There is a small sitting area with plush leather armchairs, and a fun spiral walkway with numbered tiles that resembles the children’s game of hopscotch. To the side, a selection of pastries with tea and coffee are offered to guests. In the restaurant, The Game, the benches along the walls are lined with cushions decorated like traditional dice showing all six different sides. Overall, the public areas are simple, organized, and clean.

The hotel is not exactly in the city center, and because of its location next to a large hospital, the area can become busy and noisy. 

About a five-minute walk from the Best Western Globus is San Lorenzo, a historic district  that has plenty of pizzerias, trattorias serving local cuisine, pubs, and shops, many of them catering to the  massive student population at Sapienza. While not a typical tourist destination, San Lorenzo is best for experiencing local culture, capturing local street art, and tracking down flea markets.

Such top sights as Vatican City, which includes St. Peter's Basilica, the Vatican museums, and and the Vatican Gardens, and the Colosseum are within a 30-minute taxi ride. For Renaissance and Baroque art, the Galleria Borghese is a 30-minute walk from the hotel, and San Luigi dei Francesi, another example of Renaissance art, is another 30-minute  walk from Galleria Borghese.

Rooms are simple, with white color schemes and little if no accents. There are six room options, including Suite Sweetly, Working, Dynamic, Fantasy, Dreaming Junior Suite, and Liberty, ranging in size to accommodate one to four people. Rooms have flat-screen TVs, mini-fridges, air-conditioning, and free Wi-Fi. Larger rooms have private balconies with dining areas. Room service is available. Bathrooms have stand-in showers with rain showerheads.

The Game is a buffet restaurant located on the hotel's main floor. Breakfast is free for all hotel guests. The selection includes pastries, fruits, yogurts, cheeses, and hot meats. For lunch, the restaurant offers local Italian cuisine.