The hotel is located directly behind the baroque Moses Fountain on a street lined with orange trees. Guests enter through a nondescript rustic wooden door on one side and climb several flights of stone steps to reach their rooms, each of which has an individualized look and color scheme. Note that there’s no reception area.

Moses Fountain Hotel is situated in a bustling area of Rome filled with corporate headquarters and financial institutions, which also means there are many restaurants and shops to serve the working population. Villa Borghese, Rome's central park, and the Spanish Steps are both a 15-minute walk away, while getting to Via Vittorio Veneto takes a 10-minute stroll. The metro station at Piazza della Repubblica is a short trek south and Termini Station, the city's central railway, is also within walking distance.

Rooms are large, quiet, and beautifully decorated in a contemporary style that contrasts with the historic surroundings. Each of the six rooms have unique names like Velvet Indigo, Theresa’s Sofa, Swanky Cardinal, and Turtle Dove. Modern amenities include comfortable beds, flat-screen TVs, and complimentary minibars that are re-stocked with snacks and beverages each day. Luxurious tiled bathrooms include rain showers, large soaking tubs, and upscale towels and toiletries.

Free Wi-Fi is available throughout the property. Laundry service is also offered, and there’s parking nearby. An ample free breakfast is included as well, which can be delivered to one's room or enjoyed as a buffet on the terrace during the warmer months.