The 42 luxurious rooms of Ca’Sagredo were designed in aristocratic Venetian style. This restored pink palazzo on the Grand Canal has maintained its original grandeur, including salons filled with frescoes and sweeping staircases. Huge rooms have plush furnishings and marble bathrooms; the terrace along the canal is a scenic place for a drink. This is one of the most decadent hotel experiences in Venice, and it's right on the Grand Canal, within walking distance of St. Mark's Square.

The Luna Hotel Baglioni is a luxury chain hotel with 104 rooms located less than a two-minute walk from the shops, restaurants, and architecture of Saint Mark’s Square. The classic hotel delivers a high level of service in a beautiful setting. Canova, an award-winning restaurant serving Italian and international cuisine, is on-site along with a café and full bar.

A luxurious, 72-room converted palazzo in the northern edge of Venice, Boscolo Venezia Autograph Collection is a quiet retreat from the chaotic heart of the city. The rare, private garden and spa with hot tub, sauna, and steam room are highlights. Rooms have classic decor and Venetian portraits, but upgrading to a Junior Suite gets guests more space and style -- these rooms have high ceilings and intricate crown molding. The hotel's location is far from Venice's main attractions, but it does offer free water taxi service to St. Mark's Square and Murano.

The Centurion Palace is a 50-room luxury hotel housed in a 19th-century palace. Its location is excellent, right on the Grand Canal and sandwiched between the Peggy Guggenheim Museum and Santa Maria della Salute. Inside, the decor is chic and opulent, and all 50 rooms are individually decorated with stylish and quirky touches. The on-site restaurant with canal views serves wonderful food, and the terrace is lovely when it's warm enough for alfresco dining.

The 119-room Bauer Hotel is a convenient two-minute walk from St. Mark's Square in the heart of Venice. This exclusive Art Deco-influenced property has a grand lobby full of gold accents and chandeliers as well as traditionally decorated rooms with high ceilings and big, modern bathrooms. The hotel features a restaurant and two two bars; Bar Canale has an outdoor terrace and Grand Canal views. There is nice variety in the daily breakfast buffet, but rooms lack tea or coffee facilities.